反应详情

温度

170 °C

A mixture of 2-chloro-8-methoxy-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine (40 mg) in 2-methyl-1-butylamine (117 mg) was heated in a microwave at 170° C. for 15 mins. The mixture was concentrated in vacuo to give a green oily residue which was purified by C18 reverse phase chromatography (ISCO) using water (0.1% formic acid)-acetonitrile (0.05% formic acid) as eluent (20-60%) to give the title compound as an off-white solid (9 mg).

1. concentrationThe mixture was concentrated in vacuo
2. customto give a green oily residue which
3. customwas purified by C18 reverse phase chromatography (ISCO)