HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1011167Generated: November 1, 2026
2-Chloro-8-methoxy-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-Purin-6-amine → 6-Amino-2-[(2-methylbutyl)amino]-9-(tetrahydro-2H-Pyran-4-ylmethyl)-7,9-dihydro-8H-Purin-8-one
https://huagongshe.com/reaction/1011167
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Chloro-8-methoxy-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-Purin-6-amine | HCID 57699744 | — |
| Solvent | 2-Methylbutylamine | HCID 7283 | — |
| Product | 6-Amino-2-[(2-methylbutyl)amino]-9-(tetrahydro-2H-Pyran-4-ylmethyl)-7,9-dihydro-8H-Purin-8-one | HCID 25025556 | 40.1% |
Reaction Steps
A mixture of 2-chloro-8-methoxy-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine (40 mg) in 2-methyl-1-butylamine (117 mg) was heated in a microwave at 170° C. for 15 mins. The mixture was concentrated in vacuo to give a green oily residue which was purified by C18 reverse phase chromatography (ISCO) using water (0.1% formic acid)-acetonitrile (0.05% formic acid) as eluent (20-60%) to give the title compound as an off-white solid (9 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07977344B2 |
|---|
| Source dataset | uspto-grants-2011_07 |
|---|
| ORD ID | ord-ebd163a12d5d489492bd1eda4e0c8e6e |
|---|
| Source note | uspto-grants-2011_07 |
|---|
