Hydrochloric Acid → HCID 67314132, compound

HRID 1011191Notes

Reaction equation

HRID 1011191 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH3:14])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:21])[N:6]2[CH2:15][CH:16]1[CH2:20][CH2:19][O:18][CH2:17]1.[ClH:22].[CH2:23](OCC)C>O1CCOCC1>[ClH:22].[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:23])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:21])[N:6]2[CH2:15][CH:16]1[CH2:20][CH2:19][O:18][CH2:17]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 67314393HCID 67314393, compound

Product 1

HCID 67314132HCID 67314132, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To 6-Amino-2-(propyloxy)-9-(tetrahydro-3-furanylmethyl)-7,9-dihydro-8H-purin-8-one (52.6 mg) was added an excess of 4N hydrogen chloride in 1,4-dioxane (1 mL). The resultant solution was evaporated under reduced pressure (after 5 minutes) to give a colourless gum containing some crystals. To this material was added diethyl ether to triturate out the 1,4-dioxane, giving a free flowing solid on scratching. After evaporation to dryness under reduced pressure for 2 hours (water bath at 50° C., minimum vacuo ˜38 mbar) gave the title compound (61 mg) an off-white free flowing solid.

Workup

  1. customThe resultant solution was evaporated under reduced pressure (after 5 minutes)
  2. customto give a colourless gum
  3. additioncontaining some crystals
  4. customto triturate out the 1,4-dioxane
  5. customgiving
  6. customAfter evaporation to dryness under reduced pressure for 2 hours (water bath at 50° C., minimum vacuo ˜38 mbar)

Sources & evidence

ORD record
ord-cddb8cc953f447018eb3e883815a5e2d
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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