反应详情

To 6-amino-2-(butylamino)-9-(tetrahydro-3-furanylmethyl)-7,9-dihydro-8H-purin-8-one (isomer 1) (1.0 g) at room temperature and under nitrogen, was added 4.0M hydrochloric acid in 1,4-dioxane (10.61 ml) and the reaction stirred for 30 minutes. The reaction was then concentrated in vacuo and left on the rotary evaporator for 2 hours at 50° C. The beige solid was recrystallised overnight from 2-butanone (18 ml). The crystals were collected by suction filtration and dried in vacuo at 50° C. for 30 minutes (850 mg).

1. concentrationThe reaction was then concentrated in vacuo
2. waitleft on the rotary evaporator for 2 hours at 50° C
3. customThe beige solid was recrystallised overnight from 2-butanone (18 ml)
4. filtrationThe crystals were collected by suction filtration
5. customdried in vacuo at 50° C. for 30 minutes (850 mg)