Hydrochloric Acid → HCID 25026558, compound

Participants

Reaction Steps

To a solution of 2-(butyloxy)-8-(methyloxy)-9-[4-(tetrahydro-2H-pyran-3-yl)butyl]-9H-purin-6-amine (135 mg, 0.358 mmol) in methanol (10 ml) was added 4M HCl in dioxane (2.235 ml, 8.94 mmol) and the mixture was left standing at 20° C. for 18 hours. The solvent was evaporated in vacuo to give a white solid which was loaded in methanol onto a 10 g aminopropyl SPE cartridge and eluted with methanol. The appropriate fractions were combined and evaporated in vacuo to give the title compound as a white solid (50 mg).

Provenance & Evidence