Hydrochloric Acid → HCID 25026558, compound

HRID 1011207Notes

Reaction equation

HRID 1011207 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:25]C)[N:12]2[CH2:15][CH2:16][CH2:17][CH2:18][CH:19]2[CH2:24][CH2:23][CH2:22][O:21][CH2:20]2)=[C:8]([NH2:27])[N:7]=1)[CH2:2][CH2:3][CH3:4].Cl.O1CCOCC1>CO>[NH2:27][C:8]1[N:7]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:25])[N:12]2[CH2:15][CH2:16][CH2:17][CH2:18][CH:19]1[CH2:24][CH2:23][CH2:22][O:21][CH2:20]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 57699770HCID 57699770, compound

Product 1

HCID 25026558HCID 25026558, compoundYield 38.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of 2-(butyloxy)-8-(methyloxy)-9-[4-(tetrahydro-2H-pyran-3-yl)butyl]-9H-purin-6-amine (135 mg, 0.358 mmol) in methanol (10 ml) was added 4M HCl in dioxane (2.235 ml, 8.94 mmol) and the mixture was left standing at 20° C. for 18 hours. The solvent was evaporated in vacuo to give a white solid which was loaded in methanol onto a 10 g aminopropyl SPE cartridge and eluted with methanol. The appropriate fractions were combined and evaporated in vacuo to give the title compound as a white solid (50 mg).

Workup

  1. waitthe mixture was left
  2. customThe solvent was evaporated in vacuo
  3. customto give a white solid which
  4. washeluted with methanol
  5. customevaporated in vacuo

Sources & evidence

ORD record
ord-4055fac4cc7543aa8598aea544c3a4b2
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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