反应详情

To a solution of 2-[(2-cyclopropylethyl)oxy]-8-(methyloxy)-9-[2-(tetrahydro-2-furanyl)ethyl]-9H-purin-6-amine (88 mg, 0.253 mmol) in methanol (10 ml) at room temperature was added 4M HCl in 1,4 dioxane (2.106 ml, 8.42 mmol) to give a pale straw coloured solution. The reaction mixture was stirred at ambient temperature overnight (16 hours) and then loaded in methanol onto a 5 g aminopropyl SPE cartridge and eluted with methanol. The filtrate was evaporated on a nitrogen blowdown unit to give the title compound as a white solid (41 mg).

1. customto give a pale straw coloured solution
2. washeluted with methanol
3. customThe filtrate was evaporated on a nitrogen