反应详情

To a solution of 2-[(2-cyclopropylethyl)oxy]-8-(methyloxy)-9-[2-(tetrahydro-2H-pyran-2-yl)ethyl]-9H-purin-6-amine (84.7 mg, 0.234 mmol) in methanol (7.9 ml) at room temperature was added 4.0 M HCl in 1,4-dioxane (1.46 ml) to give a pale straw coloured solution. The reaction mixture was stirred at ambient temperature overnight (20 hours) and then evaporated in vacuo to give a colourless oil/gum. This material was re-dissolved in methanol and passed down a 5 g aminopropyl SPE cartridge (pre-conditioned in methanol), washed through with methanol and evaporated to give the title compound as a white solid (58.5 mg).

1. customto give a pale straw coloured solution
2. customevaporated in vacuo
3. customto give a colourless oil/gum
4. washwashed through with methanol
5. customevaporated