反应详情

To a solution of 2-{[(1R)-1-methylbutyl]oxy}-8-(methyloxy)-9-[3-(tetrahydro-3-furanyl)propyl]-9H-purin-6-amine (52 mg, 0.143 mmol) in methanol (5 ml) at room temperature was added 4M HCl in dioxane (0.894 ml, 3.58 mmol). The reaction mixture was stirred at room temperature for 18 hrs and concentrated in vacuo to give a white solid. This material was dissolved in methanol and loaded onto a 2 g aminopropyl SPE cartridge, eluting with methanol. The solvent was removed to give the title compound as a white solid (36 mg).

1. concentrationconcentrated in vacuo
2. customto give a white solid
3. washeluting with methanol
4. customThe solvent was removed