HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 7016849, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (S)-1-Boc-3-(2-ethoxy-2-oxoethyl)piperidine | HCID 29919086 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 7016849 | HCID 7016849 | — |
Reaction Steps
280 mg (1.03 mmol) of ethyl (S)-(1-tert-butoxycarbonylpiperidin-3-yl)acetate (Example 16A) are stirred with 2 ml of dichloromethane and 2 ml of trifluoroacetic acid at RT for 1 h. The volatile components are removed on a rotary evaporator and the residue is dried under high vacuum. The resulting oil (290 mg, 99% of theory) is reacted further as it is.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977349B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-ebb6fff3d860401a8e37e620b50e3b85 |
| Source note | uspto-grants-2011_07 |