Trifluoroacetic acid → HCID 7016849, compound

HRID 1011218Notes

Reaction equation

HRID 1011218 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@@H:10]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH:8]1[CH2:13][CH2:12][CH2:11][C@@H:10]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:9]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 29919086(S)-1-Boc-3-(2-ethoxy-2-oxoethyl)piperidine

Product 1

HCID 7016849HCID 7016849, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

280 mg (1.03 mmol) of ethyl (S)-(1-tert-butoxycarbonylpiperidin-3-yl)acetate (Example 16A) are stirred with 2 ml of dichloromethane and 2 ml of trifluoroacetic acid at RT for 1 h. The volatile components are removed on a rotary evaporator and the residue is dried under high vacuum. The resulting oil (290 mg, 99% of theory) is reacted further as it is.

Workup

  1. customThe volatile components are removed on a rotary evaporator
  2. customthe residue is dried under high vacuum
  3. customThe resulting oil (290 mg, 99% of theory) is reacted further as it

Sources & evidence

ORD record
ord-ebb6fff3d860401a8e37e620b50e3b85
Source dataset
uspto-grants-2011_07
Patent number
US07977349B2

Reaction notes

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