HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → ethyl 2-[(3R)-piperidin-3-yl]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (R)-1-Boc-3-piperidine acetate ethyl ester | HCID 29919087 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | ethyl 2-[(3R)-piperidin-3-yl]acetate | HCID 7161133 | — |
Reaction Steps
290 mg (1.07 mmol) of ethyl (R)-(1-tert-butoxycarbonylpiperidin-3-yl)acetate (Example 17A) are stirred with 2 ml of dichloromethane and 2 ml of trifluoroacetic acid at RT for 1 h. The volatile components are removed on a rotary evaporator and the residue is dried under high vacuum. The resulting oil (301 mg, 99% of theory) is reacted further as it is.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977349B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-6e8ce1c5c0df4bb19ad5fefad24fc4c7 |
| Source note | uspto-grants-2011_07 |