Ethyl 4-piperidinecarboxylate → HCID 57780981, compound

HRID 1011222Notes

Reaction equation

HRID 1011222 reaction equation
B(F)(F)[O:2][C:3]([C:5]1[C:14](=[O:15])[C:13]2[C:8](=[C:9]([O:18][CH3:19])[C:10](F)=[C:11]([F:16])[CH:12]=2)[N:7]([CH2:20][C:21]([F:24])([F:23])[F:22])[CH:6]=1)=[O:4].[NH:27]1[CH2:32][CH2:31][CH:30]([C:33]([O:35][CH2:36][CH3:37])=[O:34])[CH2:29][CH2:28]1>>[CH2:36]([O:35][C:33]([CH:30]1[CH2:31][CH2:32][N:27]([C:10]2[C:9]([O:18][CH3:19])=[C:8]3[C:13]([C:14](=[O:15])[C:5]([C:3]([OH:2])=[O:4])=[CH:6][N:7]3[CH2:20][C:21]([F:23])([F:22])[F:24])=[CH:12][C:11]=2[F:16])[CH2:28][CH2:29]1)=[O:34])[CH3:37]

Participants

3

Reactant 2

HCID 70770Ethyl 4-piperidinecarboxylateHCID 57794150HCID 57794150, compound

Product 1

HCID 57780981HCID 57780981, compound

Procedure

According to the same method as for Example 46A, from 800 mg (2.08 mmol) of [6,7-difluoro-8-methoxy-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinolin-3-yl]carbonyl difluoroborate (Example 38A) and 653 mg (4.15 mmol) of ethyl piperidine-4-carboxylate, 625 mg (63% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-5ac0c70835e44cdf81e298e6e6020f99
Source dataset
uspto-grants-2011_07
Patent number
US07977349B2

Reaction notes

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