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HRID1011248

反应详情

EQUATION

反应方程式

HRID 1011248 的结构方程式

REACTANTS

反应物

3
结构：O=[N+]([O-])c1ccc(F)cc1
HCID9590

1-Fluoro-4-nitrobenzene

C6H4FNO2

结构：C[C@@H]1CNC[C@H](C)N1
HCID6950261

rel-(2R,6S)-2,6-Dimethylpiperazine

C6H14N2

结构：C[C@@H]1CN(c2ccc([N+](=O)[O-])cc2F)[C@@H](C)CN1
HCID57664344

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H]1CN(c2ccc([N+](=O)[O-])cc2)C[C@H](C)N1
HCID7059963

未命名化合物

收率 95%

PROCEDURE

实验过程

Crude cis-3,5-Dimethyl-1-(4-nitrophenyl)piperazine (4.91 g, 95% recovery) is prepared according to the method described above for the synthesis of racemic-1-(2-fluoro-4-nitrophenyl)-trans-2,5-dimethylpiperazine by treatment of 1-fluoro-4-nitrobenzene (3.08 g, 21.8 mmol) with cis-2,6-dimethylpiperazine (2.50 g, 21.8 mmol). The crude product is used in the next step without chromatographic purification. LCMS-ESI (m/z): calcd for C12H17N3O2, 235; [M+H]+ found, 236.

WORKUP

后处理

  1. customThe crude product is used in the next step without chromatographic purification