HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Fluoronitrobenzene → cis-3,5-Dimethyl-1-(4-nitrophenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Reactant | rel-(2R,6S)-2,6-dimethylpiperazine | HCID 6950261 | — |
| Reactant | Racemic-1-(2-fluoro-4-nitrophenyl)-trans-2,5-dimethylpiperazine | HCID 57664344 | — |
| Product | cis-3,5-Dimethyl-1-(4-nitrophenyl)piperazine | HCID 7059963 | 95% |
Reaction Steps
Crude cis-3,5-Dimethyl-1-(4-nitrophenyl)piperazine (4.91 g, 95% recovery) is prepared according to the method described above for the synthesis of racemic-1-(2-fluoro-4-nitrophenyl)-trans-2,5-dimethylpiperazine by treatment of 1-fluoro-4-nitrobenzene (3.08 g, 21.8 mmol) with cis-2,6-dimethylpiperazine (2.50 g, 21.8 mmol). The crude product is used in the next step without chromatographic purification. LCMS-ESI (m/z): calcd for C12H17N3O2, 235; [M+H]+ found, 236.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977352B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-dcb79cfffd694d5b81d9d2619a842aa9 |
| Source note | uspto-grants-2011_07 |