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HRID1011250

反应详情

EQUATION

反应方程式

HRID 1011250 的结构方程式

REACTANTS

反应物

3
结构：O=[N+]([O-])c1ccc(F)cc1
HCID9590

1-Fluoro-4-nitrobenzene

C6H4FNO2

结构：C[C@@H]1CN[C@@H](C)CN1
HCID220672

trans-2,5-Dimethylpiperazine

C6H14N2

结构：C[C@@H]1CN(c2ccc([N+](=O)[O-])cc2F)[C@@H](C)CN1
HCID57664344

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H]1CN(c2ccc([N+](=O)[O-])cc2)[C@@H](C)CN1
HCID57664370

rel-(2R,5S)-2,5-Dimethyl-1-(4-nitrophenyl)piperazine

C12H17N3O2

收率 31%

PROCEDURE

实验过程

Racemic-[trans-2,5-dimethyl-1-(4-nitrophenyl)piperazine] (6.34 g, 31%) is prepared according to the method described above for the synthesis of racemic-1-(2-fluoro-4-nitrophenyl)-trans-2,5-dimethylpiperazine by treatment of 1-fluoro-4-nitrobenzene (12.3 g, 87.5 mmol) with trans-2,5-dimethylpiperazine (10.0 g, 87.5 mmol). LCMS-ESI (m/z): calcd for C12H17N3O2, [M+H]+235; found, 236.