HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Fluoronitrobenzene → (2S,5R)-2,5-Dimethyl-1-(4-nitrophenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Reactant | 2,5-Dimethylpiperazine, trans- | HCID 220672 | — |
| Reactant | Racemic-1-(2-fluoro-4-nitrophenyl)-trans-2,5-dimethylpiperazine | HCID 57664344 | — |
| Product | (2S,5R)-2,5-Dimethyl-1-(4-nitrophenyl)piperazine | HCID 57664370 | 31% |
Reaction Steps
Racemic-[trans-2,5-dimethyl-1-(4-nitrophenyl)piperazine] (6.34 g, 31%) is prepared according to the method described above for the synthesis of racemic-1-(2-fluoro-4-nitrophenyl)-trans-2,5-dimethylpiperazine by treatment of 1-fluoro-4-nitrobenzene (12.3 g, 87.5 mmol) with trans-2,5-dimethylpiperazine (10.0 g, 87.5 mmol). LCMS-ESI (m/z): calcd for C12H17N3O2, [M+H]+235; found, 236.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977352B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-a172ba563a3543589bbce44ca5278f36 |
| Source note | uspto-grants-2011_07 |