HuagongsheHuagongshe Chemistry Print Report · For research reference only
Racemic-1-(2-fluoro-4-nitrophenyl)-trans-2,4,5-trimethylpiperazine → Racemic-trans-[1,2,5-trimethyl-4-(4-nitrophenyl)piperazine]
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Racemic-1-(2-fluoro-4-nitrophenyl)-trans-2,4,5-trimethylpiperazine | HCID 57664351 | — |
| Reactant | (2S,5R)-2,5-Dimethyl-1-(4-nitrophenyl)piperazine | HCID 57664370 | — |
| Product | Racemic-trans-[1,2,5-trimethyl-4-(4-nitrophenyl)piperazine] | HCID 131729017 | 111% |
Reaction Steps
Crude racemic-trans-[1,2,5-trimethyl-4-(4-nitrophenyl)piperazine] (7.48 g, 111% recovery) is prepared according to the method described above for the synthesis of racemic-1-(2-fluoro-4-nitrophenyl)-trans-2,4,5-trimethylpiperazine from racemic-[trans-2,5-dimethyl-1-(4-nitrophenyl)-piperazine] (6.34 g, 25.0 mmol). LCMS-ESI (m/z): calcd for C13H19N3O2, 249; [M+H]+ found, 250.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977352B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-d751e06db7b546bba27dbd8a44392bb0 |
| Source note | uspto-grants-2011_07 |