HuagongsheHuagongshe Chemistry Print Report · For research reference only
Racemic-1-(2-fluoro-4-nitrophenyl)-trans-2,4,5-trimethylpiperazine → cis-4-(2-Fluoro-4-nitrophenyl)-1,2,6-trimethylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Racemic-1-(2-fluoro-4-nitrophenyl)-trans-2,4,5-trimethylpiperazine | HCID 57664351 | — |
| Reactant | (3R,5S)-1-(2-Fluoro-4-nitrophenyl)-3,5-dimethylpiperazine | HCID 57664386 | — |
| Product | cis-4-(2-Fluoro-4-nitrophenyl)-1,2,6-trimethylpiperazine | HCID 57664380 | 100% |
Reaction Steps
Crude cis-4-(2-Fluoro-4-nitrophenyl)-1,2,6-trimethylpiperazine (6.1 g, 100% recovery) is prepared according to the method described above for the synthesis of racemic-1-(2-fluoro-4-nitrophenyl)-trans-2,4,5-trimethylpiperazine from 1-(2-fluoro-4-nitrophenyl)-cis-3,5-dimethylpiperazine (5.71 g, 24.2 mmol). LCMS-ESI (m/z): calcd for C13HBFN3O2, 267; [M+H]+ found, 268.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977352B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-ecbe40f27deb42c990cd04e8cda1e2df |
| Source note | uspto-grants-2011_07 |