m-Chloroperbenzoic acid → HCID 67314368, compound

HRID 1011337Notes

Reaction equation

HRID 1011337 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]2[CH2:8][O:9][C:10](=[O:11])[C:5]2=[CH:4][CH:3]=1.ClC1C=C(C=CC=1)C(OO)=[O:17]>C(Cl)(Cl)Cl.ClCCl>[CH3:1][C:2]1[N+:7]([O-:17])=[C:6]2[CH2:8][O:9][C:10](=[O:11])[C:5]2=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 58478770HCID 58478770, compound

Product 1

HCID 67314368HCID 67314368, compoundYield 73.9%

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 6344DichloromethaneSolvent

Procedure

A solution of 2-methyl-7H-furo[3,4-b]pyridin-5-one (150 mg, 1.0 mmol) in chloroform (5 mL) and dichloromethane (1 mL) is treated with m-chloroperoxybenzoic acid (258 mg, 1.5 mmol). The reaction mixture is stirred at room temperature overnight. The reaction mixture is concentrated and the residue is purified by chromatography (silica gel). The product containing fractions are concentrated to give the title compound as a solid (122 mg, 73%).

Workup

  1. concentrationThe reaction mixture is concentrated
  2. customthe residue is purified by chromatography (silica gel)
  3. additionThe product containing fractions
  4. concentrationare concentrated

Sources & evidence

ORD record
ord-c4347257a2da4b3aa6bc7822e3403615
Source dataset
uspto-grants-2011_07
Patent number
US07977351B2

Reaction notes

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