3-Hydroxypiperidine → HCID 67314128, compound

HRID 1011362Notes

Reaction equation

HRID 1011362 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[C:12]1[C:20]2[C:15](=[N:16][C:17]([CH:21]=[CH2:22])=[CH:18][CH:19]=2)[CH2:14][O:13]1.[OH:23][CH:24]1[CH2:29][CH2:28][CH2:27][NH:26][CH2:25]1>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[C:12]1[C:20]2[C:15](=[N:16][C:17]([CH2:21][CH2:22][N:26]3[CH2:27][CH2:28][CH2:29][CH:24]([OH:23])[CH2:25]3)=[CH:18][CH:19]=2)[CH2:14][O:13]1

Participants

3

Reactant 2

HCID 232933-HydroxypiperidineHCID 67314553HCID 67314553, compound

Product 1

HCID 67314128HCID 67314128, compoundYield 67%

Procedure

Following the method described in Example 19, 5-fluoro-3-(2-vinyl-7H-furo[3,4-b]pyridin-5-ylidene)-1,3-dihydro-indol-2-one (50 mg, 0.17 mmol) and 3-hydroxypiperidine (300 mg, 2.67 mmol) are reacted to provide the title compound (45 mg, 67%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-2a111eb38cd14fc18d76633f404c2be8
Source dataset
uspto-grants-2011_07
Patent number
US07977351B2

Reaction notes

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