Ethyl 4-piperidinecarboxylate → HCID 67314272, compound

HRID 1011363Notes

Reaction equation

HRID 1011363 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[C:12]1[C:20]2[C:15](=[N:16][C:17]([CH:21]=[CH2:22])=[CH:18][CH:19]=2)[CH2:14][O:13]1.[NH:23]1[CH2:33][CH2:32][CH:26]([C:27]([O:29][CH2:30][CH3:31])=[O:28])[CH2:25][CH2:24]1>>[CH2:30]([O:29][C:27]([CH:26]1[CH2:32][CH2:33][N:23]([CH2:22][CH2:21][C:17]2[N:16]=[C:15]3[CH2:14][O:13][C:12](=[C:5]4[C:4]5[C:8](=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=5)[NH:7][C:6]4=[O:11])[C:20]3=[CH:19][CH:18]=2)[CH2:24][CH2:25]1)=[O:28])[CH3:31]

Participants

3

Reactant 2

HCID 70770Ethyl 4-piperidinecarboxylateHCID 67314553HCID 67314553, compound

Product 1

HCID 67314272HCID 67314272, compoundYield 26.1%

Procedure

Following the method described in Example 19, 5-fluoro-3-(2-vinyl-7H-furo[3,4-b]pyridin-5-ylidene)-1,3-dihydro-indol-2-one (50 mg, 0.17 mmol) and ethyl isonipecotate (300 mg, 1.96 mmol) are reacted to provide the title compound (20 mg, 26%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-d2022f3a765648cb84e68b15739440c2
Source dataset
uspto-grants-2011_07
Patent number
US07977351B2

Reaction notes

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