1-Methylpiperazine → HCID 58478783, compound

HRID 1011380Notes

Reaction equation

HRID 1011380 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[N:6][C:7]([CH2:11][CH2:12][CH:13]=O)=[CH:8][CH:9]=2)[CH2:4][O:3]1.[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>>[CH3:15][N:16]1[CH2:21][CH2:20][N:19]([CH2:13][CH2:12][CH2:11][C:7]2[N:6]=[C:5]3[CH2:4][O:3][C:2](=[O:1])[C:10]3=[CH:9][CH:8]=2)[CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 58478730HCID 58478730, compound

Product 1

HCID 58478783HCID 58478783, compoundYield 84%

Procedure

In a process similar to that described in Preparation 8, 3-(5-Oxo-5,7-dihydro-furo[3,4-b]pyridin-2-yl)-propionaldehyde (63 mg, 0.33 mmol) and 1-methylpiperazine (33 mg, 0.33 mmol) are reacted to provide the title compound as white solid (76 mg, 84%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-42a0936e9930450abc86510d273a2b17
Source dataset
uspto-grants-2011_07
Patent number
US07977351B2

Reaction notes

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