反应详情

温度

50 °C

A solution of 1-bromoisoquinoline (2.06 g, 10 mmol), prepared as described in European Journal of Organic Chemistry 2002, 4181-4184, 2-methoxyphenylboronic acid (2.79 g, 10 mmol), Pd(PPh3)4 (5% mol), K2CO3 (5 g) in DMF/water (3/1) is stirred at 50° C. for 12 hours. The reaction mixture is then pored on water (150 mL). The aqueous phase is extracted with ethyl acetate (3×100 mL). The combined organic layers are washed with water (3×200 mL). The organic phase is dried over magnesium sulfate and evaporated under vacuum to afford the title compound.

1. extractionThe aqueous phase is extracted with ethyl acetate (3×100 mL)
2. washThe combined organic layers are washed with water (3×200 mL)
3. dry with materialThe organic phase is dried over magnesium sulfate
4. customevaporated under vacuum