Sodium Chloride → 2-Hydroxypropyl-Beta-Cyclodextrin

Participants

Reaction Steps

40 mg (0.13 mmol) of compound described in example 2 and 1.46 g of hydroxypropyl-beta-cyclodextrin (DS 0.58-Mw 1386 g.·L−1) were dissolved in 15 mL of dichloromethane and 10 mL of methanol. The limpid mixture was evaporated under reduced pressure at room temperature giving 1.80 g of a pale yellow powder containing 2 wt % of product described in example 2 (mol/mol ratio for the complex “dihydro-compound/beta-cyclodextrine”: ⅛). The included molecule is now soluble (10 g·L−1) in a mixture of 9 wt % NaCl aqueous solution (80 Vol. %), dimethylsulfoxide (10 Vol. %) and Chremofor EL (10 Vol. %).

Provenance & Evidence