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HRID1011448

反应详情

EQUATION

反应方程式

HRID 1011448 的结构方程式

REACTANTS

反应物

2
结构：[Cl-].[Na+]
HCID5234

Sodium chloride

ClNa

结构：OC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O[C@H]8[C@H](O)[C@@H](O)[C@@H](O[C@H]1[C@H](O)[C@H]2O)O[C@@H]8CO)O[C@@H]7CO)O[C@@H]6CO)O[C@@H]5CO)O[C@@H]4CO)O[C@@H]3CO
HCID444041

beta-Cyclodextrin

C42H70O35

PRODUCTS

生成物

1
结构：CC(O)COC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O[C@H]8[C@H](O)[C@@H](O)[C@@H](O[C@H]1[C@H](O)[C@H]2O)O[C@@H]8COCC(C)O)O[C@@H]7COCC(C)O)O[C@@H]6COCC(C)O)O[C@@H]5COCC(C)O)O[C@@H]4COCC(C)O)O[C@@H]3COCC(C)O
HCID14049689

6A,6B,6C,6D,6E,6F,6G-Heptakis-O-(2-hydroxypropyl)-β-cyclodextrinr

C63H112O42

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CS(C)=O
溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

40 mg (0.13 mmol) of compound described in example 2 and 1.46 g of hydroxypropyl-beta-cyclodextrin (DS 0.58-Mw 1386 g.·L−1) were dissolved in 15 mL of dichloromethane and 10 mL of methanol. The limpid mixture was evaporated under reduced pressure at room temperature giving 1.80 g of a pale yellow powder containing 2 wt % of product described in example 2 (mol/mol ratio for the complex “dihydro-compound/beta-cyclodextrine”: ⅛). The included molecule is now soluble (10 g·L−1) in a mixture of 9 wt % NaCl aqueous solution (80 Vol. %), dimethylsulfoxide (10 Vol. %) and Chremofor EL (10 Vol. %).

WORKUP

后处理

  1. additioncontaining 2 wt % of product