HCID 59511048, compound → HCID 59511056, compound

HRID 1011463Notes

Reaction equation

HRID 1011463 reaction equation
[N:1]([CH2:4][CH:5]([OH:8])[CH2:6][F:7])=[N+:2]=[N-:3].[C:9]([N:12]1[CH:16]=[CH:15][N:14]=[C:13]1[N+:17]([O-:19])=[O:18])#[C:10][CH3:11]>>[F:7][CH2:6][CH:5]([OH:8])[CH2:4][N:1]1[CH:11]=[C:10]([CH2:9][N:12]2[CH:16]=[CH:15][N:14]=[C:13]2[N+:17]([O-:19])=[O:18])[N:3]=[N:2]1

Participants

3

Reactant 2

HCID 59511048HCID 59511048, compoundHCID 66850847HCID 66850847, compound

Product 1

HCID 59511056HCID 59511056, compound

Conditions

Temperature
60 °C

Procedure

To a vial is added fluoroazide 17 (5.79 mmol) and 1-propynyl-2-nitroimidazole (5.79 mmol). The solution is heated at 60° C. overnight. The material is then purified on a silica gel column using EtOAc:Hex as the eluent. The material is then further purified via recrystallization using EtOAc:Hex to afford pale yellow crystals. Preparation of Compounds 5 and 21:

Workup

  1. customThe material is then purified on a silica gel column
  2. customThe material is then further purified via recrystallization
  3. customHex to afford pale yellow crystals

Sources & evidence

ORD record
ord-44b5d58d60c342ee9487cd1b452108d1
Source dataset
uspto-grants-2011_07
Patent number
US07977361B2

Reaction notes

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