Chlorotrimethylsilane → HCID 67313468, compound

HRID 1011631Notes

Reaction equation

[CH2:1]([C:5]1([N:53]([CH3:55])[CH3:54])[CH2:10][CH2:9][C:8]([C:32]2[NH:33][C:34]3[C:39]([C:40]=2[CH2:41][CH2:42][N:43]2[CH2:52][CH2:51][C:50]4[C:45](=[CH:46][CH:47]=[CH:48][CH:49]=4)[CH2:44]2)=[CH:38][CH:37]=[CH:36][CH:35]=3)([C:11]2[NH:12][C:13]3[C:18]([C:19]=2[CH2:20][CH2:21][N:22]2[CH2:31][CH2:30][C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH2:23]2)=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:7][CH2:6]1)[CH2:2][CH2:3][CH3:4].[Cl:56][Si](C)(C)C>CC(CC)=O>[ClH:56].[CH2:1]([C:5]1([N:53]([CH3:54])[CH3:55])[CH2:6][CH2:7][C:8]([C:11]2[NH:12][C:13]3[C:18]([C:19]=2[CH2:20][CH2:21][N:22]2[CH2:31][CH2:30][C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH2:23]2)=[CH:17][CH:16]=[CH:15][CH:14]=3)([C:32]2[NH:33][C:34]3[C:39]([C:40]=2[CH2:41][CH2:42][N:43]2[CH2:52][CH2:51][C:50]4[C:45](=[CH:46][CH:47]=[CH:48][CH:49]=4)[CH2:44]2)=[CH:38][CH:37]=[CH:36][CH:35]=3)[CH2:9][CH2:10]1)[CH2:2][CH2:3][CH3:4]

Participants

Conditions

Temperature: 23 °C

Procedure

1-butyl-4,4-bis-(3-(2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl)-1H-indol-2-yl)-N,N-dimethylcyclohexylamine (57 mg, 0.079 mmol) was dissolved in ethyl methyl ketone (2 ml). The solution was mixed with chlorotrimethyl silane (50 μl, 0.391 mmol) at RT. The clear reaction mixture immediately became cloudy. The mixture was stirred for 30 min at 23° C. The white precipitate was aspirated. The solid was washed with ethyl methyl ketone (3×0.5 ml) and then dried. The hydrochloride (48 mg, approx. 80%) was obtained as light beige-coloured solid.

Workup

washThe solid was washed with ethyl methyl ketone (3×0.5 ml)
customdried

Sources & evidence

ORD record: ord-25a56d51effe473c80fe5ca3b02ba06c
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07977370B2

Reaction notes

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