Chlorotrimethylsilane → HCID 67313468, compound

Participants

Reaction Conditions

Reaction Steps

1-butyl-4,4-bis-(3-(2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl)-1H-indol-2-yl)-N,N-dimethylcyclohexylamine (57 mg, 0.079 mmol) was dissolved in ethyl methyl ketone (2 ml). The solution was mixed with chlorotrimethyl silane (50 μl, 0.391 mmol) at RT. The clear reaction mixture immediately became cloudy. The mixture was stirred for 30 min at 23° C. The white precipitate was aspirated. The solid was washed with ethyl methyl ketone (3×0.5 ml) and then dried. The hydrochloride (48 mg, approx. 80%) was obtained as light beige-coloured solid.

Provenance & Evidence