反应详情

To a solution of methyl 3-[(1-methylethyl)oxy]-5-[(phenylmethyl)oxy]benzoate (37 g) in a 1:1 mixture of THF:methanol (300 mL) was added 4M sodium hydroxide solution (150 mL). The mixture was refluxed for 45 minutes, following which the organics were removed in vacuo. The aqueous was acidified to pH4 with hydrochloric acid (2M), and extracted with ethyl acetate. The organics were combined, washed with water and brine, dried (MgSO4) and concentrated in vacuo to give the desired compound (33.5 g), which was used without further purification.

1. temperatureThe mixture was refluxed for 45 minutes
2. customorganics were removed in vacuo
3. extractionextracted with ethyl acetate
4. washwashed with water and brine
5. dry with materialdried (MgSO4)
6. concentrationconcentrated in vacuo