反应详情

温度

160 °C

A solution of 1,1-dimethylethyl 3-{[(3-hydroxy-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}phenyl)carbonyl]amino}-1H-pyrazole-1-carboxylate (157 mg, 0.4 mmol) and 5-(azetidin-1-ylcarbonyl)-2-chloropyridine (95 mg, 0.48 mmol) in acetonitrile (2 mL), containing potassium carbonate (111 mg, 0.8 mmol), was heated in a microwave reactor at 160° C. for 6 hours. The reaction mixture was filtered and the filtrate evaporated to dryness under reduced pressure and purified by chromatography on silica, eluting with 50-100% ethyl acetate in hexane to give a product which was further purified by chromatography on silica, eluting with 0-8% methanol in ethyl acetate, to give the required product as a white foam (21 mg).

1. filtrationThe reaction mixture was filtered
2. customthe filtrate evaporated to dryness under reduced pressure
3. custompurified by chromatography on silica
4. washeluting with 50-100% ethyl acetate in hexane
5. customto give a product which
6. customwas further purified by chromatography on silica
7. washeluting with 0-8% methanol in ethyl acetate