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Potassium Phosphate, Tribasic → 1-{3-[(E)-2-(4-Chloro-phenyl)-vinyl]-phenyl}-3,5-dimethyl-1H-pyrazole-4-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 反応物 | trans-2-(4-Chlorophenyl)vinylboronic acid | HCID 642694 | — |
| 反応物 | 1-(3-Bromophenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid | HCID 2763997 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-{3-[(E)-2-(4-Chloro-phenyl)-vinyl]-phenyl}-3,5-dimethyl-1H-pyrazole-4-carboxylic acid | HCID 67315510 | 63% |
反応手順
In analogy to the procedure described in Example 14C], but with 2.8 eq of K3PO4, 1-(3-bromo-phenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid and trans-2-(4-chlorophenyl)vinylboronic acid gave after suspending in CH2Cl2 and filtration the title compound in 63% yield as light yellow solid. MS: 352.2 (M+, 1 Cl).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07977358B2 |
| 出典データセット | uspto-grants-2011_07 |
| ORD ID | ord-9b5c0dac91ee436c9b208f39c20e1b07 |
| 出典メモ | uspto-grants-2011_07 |