HCID 67315889, compound → HCID 57555051, compound

HRID 1011890Notes

Reaction equation

HRID 1011890 reaction equation
[CH2:1]([C:3]1[C:7]([C:8]([N:10]2[CH2:16][CH2:15][CH2:14][N:13]([CH2:17][CH2:18][OH:19])[CH2:12][CH2:11]2)=[O:9])=[C:6]([CH2:20][CH3:21])[N:5]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([C:28]#[C:29][CH2:30][CH2:31][CH2:32][CH3:33])[CH:23]=2)[N:4]=1)[CH3:2]>CO.[Pd]>[CH2:1]([C:3]1[C:7]([C:8]([N:10]2[CH2:16][CH2:15][CH2:14][N:13]([CH2:17][CH2:18][OH:19])[CH2:12][CH2:11]2)=[O:9])=[C:6]([CH2:20][CH3:21])[N:5]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[CH:23]=2)[N:4]=1)[CH3:2]

Participants

4

Reactant 1

HCID 67315889HCID 67315889, compound

Product 1

HCID 57555051HCID 57555051, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

0.027 g of Pd—C (10%) was added to a solution of 0.11 g (0.30 mmol) of [3,5-diethyl-1-(3-hex-1-ynyl-phenyl)-1H-pyrazol-4-yl]-[4-(2-hydroxy-ethyl)-[1,4]diazepan-1-yl]-methanone in 5 ml of MeOH and the reaction mixture was then hydrogenated with H2 (1 bar) at RT for 1 hour. After removal the catalyst by filtration, the solvent was evaporated completely to afford the title compound as light yellow oil. MS: 455.3 (MH+).

Workup

  1. customAfter removal the catalyst
  2. filtrationby filtration
  3. customthe solvent was evaporated completely

Sources & evidence

ORD record
ord-20c31ad3dfc5453da2540b68d21e25a7
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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