3-(Diethylamino)pyrrolidine → [5-(3-Bromo-phenyl)-2,4-dimethyl-2H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone

HRID 1011914Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1011914
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[C:9]([CH3:17])=[C:10]([C:14]([OH:16])=O)[N:11]([CH3:13])[N:12]=2)[CH:5]=[CH:6][CH:7]=1.[CH2:18]([N:20]([CH2:26][CH3:27])[CH:21]1[CH2:25][CH2:24][NH:23][CH2:22]1)[CH3:19]>>[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[C:9]([CH3:17])=[C:10]([C:14]([N:23]3[CH2:24][CH2:25][CH:21]([N:20]([CH2:26][CH3:27])[CH2:18][CH3:19])[CH2:22]3)=[O:16])[N:11]([CH3:13])[N:12]=2)[CH:5]=[CH:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 199619953-(Diethylamino)pyrrolidineHCID 67315642HCID 67315642, Verbindung

Produkt 1

HCID 67314617[5-(3-Bromo-phenyl)-2,4-dimethyl-2H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanoneAusbeute 77 %

Versuchsvorschrift

In analogy to the procedure described in example 12D), 5-(3-bromo-phenyl)-2,4-dimethyl-2H-pyrazole-3-carboxylic acid and 3-(diethylamino)pyrrolidine gave the title compound in 77% yield as light yellow viscous oil. MS: 419.0 (MH+, 1 Br).

Quellen und Nachweise

ORD-Eintrag
ord-0acad17e62ac40d3b53f117620b02091
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07977358B2

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