Iodobenzene → HCID 178463851, compound

HRID 1011925Notes

Reaction equation

HRID 1011925 reaction equation
I[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:8]([N:10]([CH2:32][CH3:33])[CH:11]1[CH2:15][CH2:14][N:13]([C:16]([C:18]2[C:22]([CH3:23])=[C:21]([C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([C:30]#[CH:31])[CH:25]=3)[NH:20][N:19]=2)=[O:17])[CH2:12]1)[CH3:9]>>[CH2:32]([N:10]([CH2:8][CH3:9])[CH:11]1[CH2:15][CH2:14][N:13]([C:16]([C:18]2[C:22]([CH3:23])=[C:21]([C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([C:30]#[C:31][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)[CH:25]=3)[NH:20][N:19]=2)=[O:17])[CH2:12]1)[CH3:33]

Participants

3

Reactant 2

HCID 11575IodobenzeneHCID 178436202(3-Diethylamino-pyrrolidin-1-yl)-[5-(3-ethynyl-phenyl)-4-methyl-1H-pyrazol-3-yl]-methanone

Product 1

HCID 178463851HCID 178463851, compoundYield 70%

Procedure

In analogy to the procedure described in Example 31F], iodobenzene and (3-diethylamino-pyrrolidin-1-yl)-[5-(3-ethynyl-phenyl)-4-methyl-1H-pyrazol-3-yl]-methanone (Example 31E]) gave the title compound in 70% yield light yellow semisolid. MS: 427.3 (MH+).

Sources & evidence

ORD record
ord-c974724f9aa94715bfb25755866676f5
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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