Benzene, 1,2-dichloro-4-iodo- → HCID 178463854, compound

HRID 1011926Notes

Reaction equation

HRID 1011926 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](I)=[CH:4][C:3]=1[Cl:9].[CH2:10]([N:12]([CH2:34][CH3:35])[CH:13]1[CH2:17][CH2:16][N:15]([C:18]([C:20]2[C:24]([CH3:25])=[C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([C:32]#[CH:33])[CH:27]=3)[NH:22][N:21]=2)=[O:19])[CH2:14]1)[CH3:11]>>[Cl:9][C:3]1[CH:4]=[C:5]([C:33]#[C:32][C:28]2[CH:27]=[C:26]([C:23]3[NH:22][N:21]=[C:20]([C:18]([N:15]4[CH2:16][CH2:17][CH:13]([N:12]([CH2:34][CH3:35])[CH2:10][CH3:11])[CH2:14]4)=[O:19])[C:24]=3[CH3:25])[CH:31]=[CH:30][CH:29]=2)[CH:6]=[CH:7][C:2]=1[Cl:1]

Participants

3

Reactant 2

HCID 88591Benzene, 1,2-dichloro-4-iodo-HCID 178436202(3-Diethylamino-pyrrolidin-1-yl)-[5-(3-ethynyl-phenyl)-4-methyl-1H-pyrazol-3-yl]-methanone

Product 1

HCID 178463854HCID 178463854, compound

Procedure

In analogy to the procedure described in Example 31F], 1,2-dichloro-4-iodobenzene and (3-diethylamino-pyrrolidin-1-yl)-[5-(3-ethynyl-phenyl)-4-methyl-1H-pyrazol-3-yl]-methanone (Example 31E]) gave the title compound in 71% yield yellow foam. MS: 495.2 (MH+, 2 Cl).

Sources & evidence

ORD record
ord-af0f39b492d14fb3b39303ef6ad3d00e
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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