4-(1-Pyrrolidinyl)piperidine → HCID 57554938, compound

HRID 1011939Notes

Reaction equation

HRID 1011939 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][C:4]=1[N:13]1[C:17]([CH3:18])=[C:16]([C:19]([OH:21])=O)[C:15]([CH3:22])=[N:14]1.[N:23]1([CH:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH2:27][CH2:26][CH2:25][CH2:24]1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][C:4]=1[N:13]1[C:17]([CH3:18])=[C:16]([C:19]([N:31]2[CH2:32][CH2:33][CH:28]([N:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)[CH2:29][CH2:30]2)=[O:21])[C:15]([CH3:22])=[N:14]1

Participants

3

Reactant 2

HCID 787034-(1-Pyrrolidinyl)piperidineHCID 67314819HCID 67314819, compound

Product 1

HCID 57554938HCID 57554938, compoundYield 27%

Procedure

In analogy to the procedure described in Example 18], 1-(2-methoxy-5-trifluoromethyl-phenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid and 4-pyrrolidine-1-yl-piperidine gave, after purification on a flash isolute NH2-column (EtOAc:n-heptane 4:1), the title compound in 27% yield as yellow oil. MS: 451.2 (MH+).

Workup

  1. customgave
  2. customafter purification on a flash isolute NH2-column (EtOAc:n-heptane 4:1)

Sources & evidence

ORD record
ord-704e06e760414a39a926824331f1cf53
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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