Ethyl 2-acetylacetoacetate → HCID 67314600, compound

HRID 1011948Notes

Reaction equation

HRID 1011948 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][NH2:9])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].[CH3:14][CH2:15][O:16][C:17]([CH:19]([C:23]([CH3:25])=O)[C:20]([CH3:22])=O)=[O:18]>>[CH2:15]([O:16][C:17]([C:19]1[C:20]([CH3:22])=[N:9][N:8]([C:5]2[CH:6]=[CH:7][C:2]([CH3:1])=[C:3]([C:10]([F:11])([F:12])[F:13])[CH:4]=2)[C:23]=1[CH3:25])=[O:18])[CH3:14]

Participants

3

Reactant 2

HCID 79063Ethyl 2-acetylacetoacetateHCID 21552091HCID 21552091, compound

Product 1

HCID 67314600HCID 67314600, compoundYield 96%

Procedure

In analogy to the procedure described in Example 38A], (4-methyl-3-trifluoromethyl-phenyl)-hydrazine and ethyl diacetoacetate gave the title compound after crystallisation (EtOAc) in 96% yield as red oil. MS: 327.3 (MH+).

Sources & evidence

ORD record
ord-128647d89de04a83b862e5b0e8aafed2
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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