2H-Isoindole-2-acetyl chloride, 1,3-dihydro-1,3-dioxo- → HCID 67314385, compound

HRID 1011982Notes

Reaction equation

HRID 1011982 reaction equation
[CH2:1]([O:3][C:4](=[O:11])[CH2:5][C:6]([CH:8]1[CH2:10][CH2:9]1)=[O:7])[CH3:2].[O:12]=[C:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15](=[O:22])[N:14]1[CH2:23][C:24](Cl)=[O:25]>>[CH2:1]([O:3][C:4](=[O:11])[CH:5]([C:6]([CH:8]1[CH2:10][CH2:9]1)=[O:7])[C:24](=[O:25])[CH2:23][N:14]1[C:15](=[O:22])[C:16]2[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:13]1=[O:12])[CH3:2]

Participants

3

Reactant 2

HCID 812422H-Isoindole-2-acetyl chloride, 1,3-dihydro-1,3-dioxo-HCID 262979Ethyl 3-cyclopropyl-3-oxopropanoate

Product 1

HCID 67314385HCID 67314385, compoundYield 60%

Procedure

In analogy to the procedure described in Example 160A], 3-cyclopropyl-3-oxo-propionic acid ethyl ester and (1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetyl chloride gave the title compound as a white solid (60%). MS: 342.1 (M−H−).

Sources & evidence

ORD record
ord-4e7d4f4122b84e6f967142abdbe8c152
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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