3-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) → HCID 67314818, compound

HRID 1011984Notes

Reaction equation

HRID 1011984 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH2:14][N:15]2[C:23](=[O:24])[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[C:16]2=[O:25])=[N:8][NH:9][C:10]=1[CH:11]1[CH2:13][CH2:12]1)=[O:5])[CH3:2].[F:26][C:27]([F:39])([F:38])[O:28][C:29]1[CH:30]=[C:31](B(O)O)[CH:32]=[CH:33][CH:34]=1>>[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH2:14][N:15]2[C:16](=[O:25])[C:17]3[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:23]2=[O:24])=[N:8][N:9]([C:31]2[CH:32]=[CH:33][CH:34]=[C:29]([O:28][C:27]([F:26])([F:38])[F:39])[CH:30]=2)[C:10]=1[CH:11]1[CH2:13][CH2:12]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 27343853-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride)HCID 178469165HCID 178469165, compound

Product 1

HCID 67314818HCID 67314818, compoundYield 54%

Procedure

In analogy to the procedure described in Example 160C], 5-cyclopropyl-3-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-1H-pyrazole-4-carboxylic acid ethyl ester and 3-(trifluoromethoxy)benzeneboronic acid gave the title compound as a white solid (54%). MS: 500.0 (MH+).

Sources & evidence

ORD record
ord-99b5a588521e4503a98830cdd0d14da9
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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