(S)-(-)-3-Acetamidopyrrolidine → N-((S)-1-{1-[5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carbonyl]-piperidin-4-yl}-pyrrolidin-3-yl)-acetamide

HRID 1012004Notes

Reaction equation

HRID 1012004 reaction equation
[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=3)[N:7]=[C:6]([CH3:19])[C:5]=2[C:20]([N:22]2[CH2:27][CH2:26][C:25](=O)[CH2:24][CH2:23]2)=[O:21])[CH2:3][CH2:2]1.[NH:29]1[CH2:33][CH2:32][C@H:31]([NH:34][C:35](=[O:37])[CH3:36])[CH2:30]1>>[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:17])([F:16])[F:18])[CH:10]=3)[N:7]=[C:6]([CH3:19])[C:5]=2[C:20]([N:22]2[CH2:27][CH2:26][CH:25]([N:29]3[CH2:33][CH2:32][C@H:31]([NH:34][C:35](=[O:37])[CH3:36])[CH2:30]3)[CH2:24][CH2:23]2)=[O:21])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 7021471(S)-(-)-3-AcetamidopyrrolidineHCID 67314190[5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carbonyl]-piperidin-4-one

Product 1

HCID 57554935N-((S)-1-{1-[5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carbonyl]-piperidin-4-yl}-pyrrolidin-3-yl)-acetamide

Procedure

The title compound was prepared from 1-[5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carbonyl]-piperidin-4-one (Example 181B) and (S)—N-pyrrolidin-3-yl-acetamide in direct analogy to the general procedure used in example 129. MS: 504.3 (MH+).

Sources & evidence

ORD record
ord-2287dccea5c1472c8c4326f00a82ec29
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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