[5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carbonyl]-piperidin-4-one → HCID 57554913, compound

HRID 1012006Notes

Reaction equation

HRID 1012006 reaction equation
[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=3)[N:7]=[C:6]([CH3:19])[C:5]=2[C:20]([N:22]2[CH2:27][CH2:26][C:25](=O)[CH2:24][CH2:23]2)=[O:21])[CH2:3][CH2:2]1.Cl.[CH3:30][C@@H:31]1[C@H:35]([OH:36])[CH2:34][CH2:33][NH:32]1>>[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:17])([F:16])[F:18])[CH:10]=3)[N:7]=[C:6]([CH3:19])[C:5]=2[C:20]([N:22]2[CH2:23][CH2:24][CH:25]([N:32]3[CH2:33][CH2:34][C@@H:35]([OH:36])[C@H:31]3[CH3:30])[CH2:26][CH2:27]2)=[O:21])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 67314190[5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carbonyl]-piperidin-4-oneHCID 673143321107659-80-2

Product 1

HCID 57554913HCID 57554913, compound

Procedure

The title compound was prepared from 1-[5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carbonyl]-piperidin-4-one (Example 181B) and (2R,3R)-2-methyl-pyrrolidin-3-ol hydrochloride (example 188A) in direct analogy to the general procedure used in example 129. MS: 477.3 (MH+).

Sources & evidence

ORD record
ord-0186666ed75a4ba5a6700189a477520a
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

Loading…