5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acid → [5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-yl]-((3S,4S)-3-methyl-4-pyrrolidin-1-yl-piperidin-1-yl)-methanone

HRID 1012012Notes

Reaction equation

HRID 1012012 reaction equation
[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=3)[N:7]=[C:6]([CH3:19])[C:5]=2[C:20](O)=[O:21])[CH2:3][CH2:2]1.Cl.Cl.[CH3:25][C@H:26]1[C@H:31]([N:32]2[CH2:36][CH2:35][CH2:34][CH2:33]2)[CH2:30][CH2:29][NH:28][CH2:27]1>>[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:16])([F:18])[F:17])[CH:10]=3)[N:7]=[C:6]([CH3:19])[C:5]=2[C:20]([N:28]2[CH2:29][CH2:30][C@H:31]([N:32]3[CH2:33][CH2:34][CH2:35][CH2:36]3)[C@@H:26]([CH3:25])[CH2:27]2)=[O:21])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 673145935-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acidHCID 67314766(trans)-3-Methyl-4-pyrrolidin-1-yl-piperidine dihydrochloride

Product 1

HCID 57554936[5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-yl]-((3S,4S)-3-methyl-4-pyrrolidin-1-yl-piperidin-1-yl)-methanone

Procedure

The title compound was prepared from 5-cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acid (Example 181A) and (trans)-3-methyl-4-pyrrolidin-1-yl-piperidine dihydrochloride (example 195C) in direct analogy to the general procedure used in example 150. MS: 461.3 (MH+).

Sources & evidence

ORD record
ord-f8fad0f541864eb89d333585559009f1
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

Loading…