((S)-1-piperidin-4-yl-pyrrolidin-2-yl)-methanol dihydrochloride → 5-Cyclopropyl-3-methyl-1-(4-trifluoromethoxy-phenyl)-1H-pyrazol-4-yl-[4-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-piperidin-1-yl]-methanone

HRID 1012022Notes

Reaction equation

HRID 1012022 reaction equation
[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][C:12]([O:15][C:16]([F:19])([F:18])[F:17])=[CH:11][CH:10]=3)[N:7]=[C:6]([CH3:20])[C:5]=2[C:21](O)=[O:22])[CH2:3][CH2:2]1.Cl.Cl.[NH:26]1[CH2:31][CH2:30][CH:29]([N:32]2[CH2:36][CH2:35][CH2:34][C@H:33]2[CH2:37][OH:38])[CH2:28][CH2:27]1>>[CH:1]1([C:4]2[N:8]([C:9]3[CH:10]=[CH:11][C:12]([O:15][C:16]([F:18])([F:19])[F:17])=[CH:13][CH:14]=3)[N:7]=[C:6]([CH3:20])[C:5]=2[C:21]([N:26]2[CH2:27][CH2:28][CH:29]([N:32]3[CH2:36][CH2:35][CH2:34][C@H:33]3[CH2:37][OH:38])[CH2:30][CH2:31]2)=[O:22])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 66901571((S)-1-piperidin-4-yl-pyrrolidin-2-yl)-methanol dihydrochlorideHCID 673148045-Cyclopropyl-3-methyl-1-(4-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid

Product 1

HCID 575550905-Cyclopropyl-3-methyl-1-(4-trifluoromethoxy-phenyl)-1H-pyrazol-4-yl-[4-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-piperidin-1-yl]-methanone

Procedure

The title compound was prepared from 5-cyclopropyl-3-methyl-1-(4-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid and ((S)-1-piperidin-4-yl-pyrrolidin-2-yl)-methanoldihydrochloride (Example 161A]) in direct analogy to the general procedure used in example 150. MS: 493.2 (MH+).

Sources & evidence

ORD record
ord-45af1dcbdb7b4b8c9f007d8c5dada1b1
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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