HuagongsheHuagongshe Chemistry Print Report · For research reference only
((S)-1-piperidin-4-yl-pyrrolidin-2-yl)-methanol dihydrochloride → 5-Cyclopropyl-3-methyl-1-(4-trifluoromethoxy-phenyl)-1H-pyrazol-4-yl-[4-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-piperidin-1-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | ((S)-1-piperidin-4-yl-pyrrolidin-2-yl)-methanol dihydrochloride | HCID 66901571 | — |
| Reactant | 5-Cyclopropyl-3-methyl-1-(4-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid | HCID 67314804 | — |
| Product | 5-Cyclopropyl-3-methyl-1-(4-trifluoromethoxy-phenyl)-1H-pyrazol-4-yl-[4-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-piperidin-1-yl]-methanone | HCID 57555090 | — |
Reaction Steps
The title compound was prepared from 5-cyclopropyl-3-methyl-1-(4-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid and ((S)-1-piperidin-4-yl-pyrrolidin-2-yl)-methanoldihydrochloride (Example 161A]) in direct analogy to the general procedure used in example 150. MS: 493.2 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977358B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-45af1dcbdb7b4b8c9f007d8c5dada1b1 |
| Source note | uspto-grants-2011_07 |