反应详情

A solution of methyl-2-(acetylamino)-3-nitrobenzoate (2.6 g) in EtOH (50 ml) was treated with concentrated hydrochloric acid (10 ml) then heated at reflux for 16 h. The reaction mixture was cooled, reduced in vacuo and azeotroped with toluene (2×50 ml) to give 2-amino-3-nitrobenzoic acid (1.83 g) as a bright yellow solid.

1. temperaturethen heated
2. temperatureat reflux for 16 h
3. temperatureThe reaction mixture was cooled
4. customazeotroped with toluene (2×50 ml)