2-Chloro-6-fluorobenzoic acid → 4-(2-Chloro-6-fluorobenzamido)-1H-pyrazole-5-carboxylic acid

HRID 1012095Notes

Reaction equation

HRID 1012095 reaction equation
[F:1][C:2]1[CH:18]=[CH:17][CH:16]=[C:15](F)[C:3]=1[C:4]([NH:6][C:7]1[C:8]([C:12]([OH:14])=[O:13])=[N:9][NH:10][CH:11]=1)=[O:5].[Cl:20]C1C=CC=C(F)C=1C(O)=O>>[Cl:20][C:15]1[CH:16]=[CH:17][CH:18]=[C:2]([F:1])[C:3]=1[C:4]([NH:6][C:7]1[C:8]([C:12]([OH:14])=[O:13])=[N:9][NH:10][CH:11]=1)=[O:5]

Participants

3

Reactant 2

HCID 679472-Chloro-6-fluorobenzoic acidHCID 178524954HCID 178524954, compound

Product 1

HCID 1785249534-(2-Chloro-6-fluorobenzamido)-1H-pyrazole-5-carboxylic acid

Procedure

The compound was prepared in a manner analogous to 4-(2,6-difluoro-benzoylamino)-1H-pyrazole-3-carboxylic acid (Example 16D), but using 2-chloro-6-fluorobenzoic acid as the starting acid to give 4-(2-chloro-6-fluoro-benzoylamino)-1H-pyrazole-3-carboxylic acid (4.42 g) as a pale blue solid. (LC/MS: Rt 2.35, [M+H]+ 283.94).

Sources & evidence

ORD record
ord-541d7ec6fa8e4512a1d2b109e7b0dc0a
Source dataset
uspto-grants-2011_07
Patent number
US07977477B2

Reaction notes

Loading…