HCID 178466989, compound → HCID 178466937, compound

HRID 1012148Notes

Reaction equation

HRID 1012148 reaction equation
[N+:1]([C:4]1[CH:30]=[CH:29][C:7]([C:8]([NH:10][C:11]2[C:12]([C:16]3[NH:20][C:19]4[CH:21]=[C:22]([O:27][CH3:28])[C:23]([O:25][CH3:26])=[CH:24][C:18]=4[N:17]=3)=[N:13][NH:14][CH:15]=2)=[O:9])=[C:6]([O:31][CH2:32][CH3:33])[CH:5]=1)([O-])=O>CCO.[Pd]>[NH2:1][C:4]1[CH:30]=[CH:29][C:7]([C:8]([NH:10][C:11]2[C:12]([C:16]3[NH:20][C:19]4[CH:21]=[C:22]([O:27][CH3:28])[C:23]([O:25][CH3:26])=[CH:24][C:18]=4[N:17]=3)=[N:13][NH:14][CH:15]=2)=[O:9])=[C:6]([O:31][CH2:32][CH3:33])[CH:5]=1

Participants

4

Reactant 1

HCID 178466989HCID 178466989, compound

Product 1

HCID 178466937HCID 178466937, compoundYield 88.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 4-nitro-N-[3-(5,6-dimethoxy-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]-2-ethoxy-benzamide (115 mg) and 10% Pd/C (20 mg) in EtOH (10 mL) was stirred under a hydrogen atmosphere for 2 h at r.t. The mixture was filtered through Celite and reduced in vacuo to give the title compound (95 mg). (LC/MS: Rt 2.11, [M+H]+ 423).

Workup

  1. filtrationThe mixture was filtered through Celite

Sources & evidence

ORD record
ord-9b356a45dca04591962481df6e74b721
Source dataset
uspto-grants-2011_07
Patent number
US07977477B2

Reaction notes

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