Trifluoroacetic acid → HCID 59468472, compound

HRID 1012190Notes

Reaction equation

HRID 1012190 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[S:12][C:11]([CH2:13][N:14](CC3C=CC(OC)=CC=3)[C:15](=[O:22])[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:10][CH:9]=2)[CH:5]=[CH:4][N:3]=1.FC(F)(F)C(O)=O.C1(S)C=CC=CC=1>C(Cl)Cl>[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[S:12][C:11]([CH2:13][NH:14][C:15](=[O:22])[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)=[CH:10][CH:9]=2)[CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7969ThiophenolHCID 59468456HCID 59468456, compound

Product 1

HCID 59468472HCID 59468472, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of N-[5-(2-Chloro-pyrimdin-4-yl)-thiophen-2-ylmethyl]-N-(4-methoxybenzyl)-benzamide (25 mg, 0.055 mmol) in 0.25 mL CH2Cl2 was treated with trifluoroacetic acid (0.25 mL) as co-solvent and PS-thiophenol resin (3 eq.) at 40° C. for 15 h. The material was filtered and concentrated to a yellow solid (16 mg, 88%). The crude material was used in the next step.

Workup

  1. filtrationThe material was filtered
  2. concentrationconcentrated to a yellow solid (16 mg, 88%)

Sources & evidence

ORD record
ord-4230a959e40a43079b79b4234b15949e
Source dataset
uspto-grants-2011_07
Patent number
US07977481B2

Reaction notes

Loading…