Hydrogen chloride-ethyl acetate → HCID 66795254, compound

HRID 1012236Notes

Reaction equation

HRID 1012236 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][C@@H:5]1[CH2:10][CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1.[ClH:18].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:18].[CH3:1][O:2][CH2:3][CH2:4][C@@H:5]1[CH2:10][CH2:9][CH2:8][NH:7][CH2:6]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 58826643HCID 58826643, compound

Product 1

HCID 66795254HCID 66795254, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of tert-butyl (S)-3-(2-methoxyethyl)piperidine-1-carboxylate (64 g, 263 mmol) in ethyl acetate (100 ml) was added 4N HCl-ethyl acetate solution (320 ml), and the mixture was stirred at room temperature for 2 hr. The solvent was evaporated under reduced pressure to give (S)-3-(2-methoxyethyl)piperidine hydrochloride as a crude product (46.7 g, yield 98%). The obtained crude product was used for Step 4 without further purification.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-9922f2ffa1d745679847559df268c9c2
Source dataset
uspto-grants-2011_07
Patent number
US07977331B1

Reaction notes

Loading…